Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells

• DOI: 10.1073/pnas.1718197115
• Publication Date: 2018-01-24T19:00:30Z
• Authors: Debangshu Samanta; Youngrok Park; Xuhao Ni; Huili Li; Cynthia A. Zahnow; Edward Gabrielson; Fan Pan; Gregg L. Semenza
• Keywords: Triple-negative breast cancer

Significance Cytotoxic chemotherapy is frequently used in patients with triple-negative breast cancer (TNBC). Although initially respond to the treatment, often comes back and kills patient. Recent studies have demonstrated that cells express genes protect them from killing by immune cells, but stimulus prompts this response unknown. We show when TNBC are treated chemotherapy, surviving turn on enable escape system. identify hypoxia-inducible factors (HIFs), which known promote metastasis of TNBC, as responsible for countertherapeutic effect. coadministration an HIF inhibitor blocks ability evade