ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma

• DOI: 10.1073/pnas.1801435115
• Publication Date: 2018-06-25T19:15:59Z
• Authors: Marco Pieraccioli; Sara Nicolai; Consuelo Pitolli; Massimiliano Agos...; Alexey Antonov; Michal Malewicz; Richard A. Knight; Giuseppe Raschellà; Gerry Melino
• Keywords: 0301 basic medicine; Prognosi; Transcription Factor; p73; Cell Line; Neoplasm Protein; neuroblastoma; Mice; Neuroblastoma; 03 medical and health sciences; Cell Line, Tumor; MYCN; ZNF281; miR34a; neuroblastoma; p73; Animals; Biomarkers, Tumor; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Proteins; Neuroblastoma; Neurons; Prognosis; Trans-Activators; Transcription Factors; Cell Differentiation; MYCN; Biomarkers, Tumor; Animals; Humans; Neurons; Neoplastic; Settore BIO/11 - BIOLOGIA MOLECOLARE; 0303 health sciences; Tumor; Animal; P73; Cell Differentiation; Neuron; Biological Sciences; Prognosis; Neoplasm Proteins; Gene Expression Regulation, Neoplastic; Repressor Proteins; Gene Expression Regulation; Trans-Activator; ZNF281; miR34a; Trans-Activators; MiR34a; Biomarkers; Human; Transcription Factors

Significance High-risk neuroblastomas (NBs) show undifferentiated/poorly differentiated morphology as a distinctive feature. We have identified the transcription factor ZNF281 that can counteract neuronal differentiation of primary neurons in culture and NB cells. The expression is inhibited by TAp73 promoted MYCN. In turn, inhibits GDNF NRP2, two proteins associated with differentiation. patients NB, higher high-risk worse prognosis. Understanding molecular mechanisms regulate relevant for identification defects this process underlie development tumors such which an aberrant arrest has occurred.