Aspirin-triggered proresolving mediators stimulate resolution in cancer

• DOI: 10.1073/pnas.1804000116
• Publication Date: 2019-03-12T20:45:15Z
• Authors: Molly M. Gilligan; Allison Gartung; Megan L. Sulciner; Paul C. Norris; Vikas P. Sukhatme; Diane R. Bielenberg; Sui Huang; Mark W. Kieran; Charles N. Serhan; Dipak Panigrahy
• Keywords: Proinflammatory cytokine

Significance Strong epidemiologic evidence indicates that aspirin is a powerful antitumorigenic agent. We now demonstrate aspirin-triggered resolvins achieve the antitumor and chemopreventive activity of without toxicity, identifying mechanism for aspirin’s anticancer activity. Our results suggest differentiating between suppression resolution inflammation highly relevant in cancer biology, revealing class endogenous mechanisms. These have pivotal implications therapy chemoprevention; unlike anti-inflammatory drugs, are active at nanogram doses not immunosuppressive. The may be harnessed to “mimic” incurring aspirin-induced such as bleeding, contain minimal residual disease.