C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis

• DOI: 10.1073/pnas.1804094115
• Publication Date: 2018-10-09T15:43:22Z
• Authors: Zaopeng Yang; Qian Li; Xin Wang; Xuepei Jiang; Dianyuan Zhao; Xin Lin; Fuchu He; Li Tang
• Keywords: Intestinal epithelium; Intestinal mucosa; C-type lectin; Homeostasis; Cytoprotection; Cell type; LGR5

Significance The clearance of apoptotic cells is critical for maintaining tissue homeostasis, and myeloid C-type lectin receptors (CLRs) may be prominently involved in the dying their debris. Here, we report that CLR member LSECtin expressed on macrophages, which are engaged corpse clearance. This engulfment progress by macrophages through intestinal healing. Loss promotes dextran sulfate sodium-induced colitis due to unrepaired epithelium. These results indicate can direct regeneration. findings advance understanding how homeostasis maintained within mucosa.