Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels

• DOI: 10.1073/pnas.1818924116
• Publication Date: 2019-03-05T21:26:31Z
• Authors: Miaorong Yu; Wenyi Song; Falin Tian; Zhuo Dai; Quanlei Zhu; Ejaj Ahmad; Shiyan Guo; Chunliu Zhu; Haijun Zhong; Yongchun Yuan; Tao Zhang; Xin Yi; Xinghua Shi; Yong Gan; Huajian Gao
• Keywords: Rigidity (electromagnetism)

Significance Lipid vesicles such as liposomes are widely present in biological systems and drug delivery applications. Numerous studies have focused on their roles intercellular communication, signaling, trafficking. Little is known, however, about the correlation between temperature transport rate of these media. Here, we report a temperature- rigidity-mediated rapid mechanism by which attain optimal diffusivity near phase transition temperature. Remarkably, with around body observed to overcome multiple barriers show substantial improvement efficacy.