The complete genome sequence ofChromobacterium violaceumreveals remarkable and exploitable bacterial adaptability

• DOI: 10.1073/pnas.1832124100
• Publication Date: 2003-10-01T19:44:34Z
• Authors: Vasconcelos, Ana ...; De-Almeida, Darcy...; Hungría, Mariangela; Guimarães, Cláudi...; Antônio, Regina V...; Almeida, Francisc...; Almeida, Luiz G.P.; Almeida, Rosana G...; Alves-Gomes, José...; Andrade, Elizabet...; Araripe, Júlia Rolão; Araújo, Magnólia ...; Astolfi-Filho, Sp...; Azevedo, Vasco Ar...; Baptista, Alessan...; Bataus, Luiz Artu...; Batista, Jacqueli...; Beló, André; Van Den Berg, Cássio; Bogo, Maurício Reis; Bonatto, Sandro L.; Bordignon, Juliano; Brígido, Marcelo ...; Brito, Cristiana ...; Brocchi, Marcelo; Burity, Hélio Alm...; Camargo, Anamaria A.; Cardoso, Divina d...; Carneiro, Newton ...; Carraro, Dirce Maria; Carvalho, Cláudia...; Mattos Cascardo, ...; Cavada, B. S.; Chueire, Lígia Ma...; Creczynski-Pasa, ...; Cunha, Nivaldo Co...; Fagundes, Nelson ...; Falcão, Clarissa ...; Fantinatti, Fabiana; Farias, Izeni P.; Felipe, Maria Sue...; Ferrari, Lilian P...; Ferro, Jesus Apar...; Ferro, Maria Inês...; Franco, Glória Re...; Freitas, Nara Suz...; Furlan, Luiz Roberto; Gazzinelli, Ricar...; Gomes, Eliane Apa...; Gonçalves, Pablo ...; Grangeiro, Thalle...; Grattapaglia, Dario; Grisard, Edmundo ...; Hanna, Ebert Seixas; Jardim, Sílvia Neto; Laurino, Jomar Pe...; Leoi, Lélia C.T.; Agnez-Lima, Lucym...; FÁtima Loureiro, ...; Lyra, Maria do Ca...; Madeira, Humberto...; Manfio, Gilson Paulo; Queiroz Maranhão,...; Martins, Wellingt...; Zingaretti, Sônia M.; Batistuzzo de Med...; Vasconcellos Meis...; Moreira, Miguel Å...; Nascimento, Fabrí...; Nicolás, Marisa F...; Oliveira, Jaquell...; Oliveira, Sérgio ...; Paixão, Roger Fer...; Parente, Juliana ...; Pedrosa, Fabio O.; Pena, Sergio Dani...; Pereira, José Odair; Pereira, Maristela; Pinto, Luciana Sa...; Pinto, Luciano Si...; Porto, Jorge Ivan...; Potrich, Deise Porto; Ramalho-Neto, Cíc...; Reis, Alessandra ...; Rigo, Liu Un; Rondinelli, Edson; do Santos, Elen B...; Santos, Fabrício ...; Schneider, Maria ...; Seuánez, Héctor N...; Silva, Ana Maria ...; Silva, Artur; Silva, Denise Wan...; Silva, Rosane A.; Carmo Simões, Isa...; Simon, Daniel; Almeida Soares, C...; Soares, Renata de...; Souza, Emanuel Ma...; Lobo de Souza, Ke...; Souza, Rangel Celso; Steffens, Maria B...; Steindel, Mário R.; Teixeira, Santuza...; Ürményi, Turán Péter; Vettore, Andre Luiz; Wassem, Roseli; Zaha, Arnaldo; Simpson, Andrew J...
• Keywords: 0301 basic medicine; paraquat; adaptation; Negibacteria; bacterial protein; open reading frame; Heavy Metal; stress; chromobacterium violaceum; bacterial genome; energy metabolism; pathogenicity; Bacteria (microorganisms); Genome; Bacterial; xenobiotic metabolism; Adaptation, Physiological; Cell Motility; Prokaryota; priority journal; chitinase; Mammalia; Priority Journal; Detoxification; signal transduction; Biotechnology; Signal Transduction; biotechnology; Paraquat; Gene Sequence; 572; membrane transport; Physiological; Molecular Sequence Data; Bacterial Protein; gene sequence; cell motility; Stress; Bacterial Enzyme; Open Reading Frame; Open Reading Frames; 03 medical and health sciences; Pathogenicity; Xenobiotic Metabolism; Adaptation; detoxification; nonhuman; bacterial enzyme; Chromobacterium; Chitinase; Nucleotide Sequence; nucleotide sequence; heavy metal; Nonhuman; carrier protein; Membrane Transport; Carrier Protein; Chromobacterium Violaceum; Energy Metabolism; Genome, Bacterial

Chromobacterium violaceumis one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) widespread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of humanC. violaceuminfection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications.