Treg-mediated prolonged survival of skin allografts without immunosuppression

• DOI: 10.1073/pnas.1903165116
• Publication Date: 2019-06-13T23:45:14Z
• Authors: Nina Pilat; Mario Wiletel; Anna M. Weijler; Romy Steiner; Benedikt Mahr; Joanna Warren; Theresa M. Corpuz; Thomas Wekerle; Kylie E. Webster; Jonathan Sprent
• Keywords: Immunosuppression; Graft rejection

Significance The use of specific IL-2/anti–IL-2 complexes (IL-2 cplxs) has shown great potency in the prevention allograft rejection mice. While long-term tolerance could be achieved toward islet allografts, clinically relevant skin graft models have remained elusive so far. Using a new protocol, this study documents that IL-2 cplxs can greatly prolong survival allografts and prevent sensitization recipient. data provide support for importance regulatory mechanisms organ-specific approaches when targeting rejection.