Conservative and disruptive modes of adolescent change in human brain functional connectivity

• DOI: 10.1073/pnas.1906144117
• Publication Date: 2020-01-28T22:32:35Z
• Authors: František Váša; Rafael Romero-Garcia; Manfred G. Kitzbi...; Jakob Seidlitz; Kirstie J. Whitaker; Matilde M. Vaghi; Prantik Kundu; Ameera X. Patel; Peter Fonagy; Raymond J. Dolan; Peter B. Jones; Ian M. Goodyer; ; Petra E. Vértes; Edward T. Bullmore; Edward Bullmore; Raymond Dolan; Ian Goodyer; Peter Fonagy; Peter Jones; Michael Moutoussis; Tobias Hauser; Sharon Neufeld; Rafael Romero-Garcia; Michelle St Clair; Petra Vértes; Kirstie Whitaker; Becky Inkster; Gita Prabhu; Cinly Ooi; Umar Toseeb; Barry Widmer; Junaid Bhatti; Laura Villis; Ayesha Alrumaithi; Sarah Birt; Aislinn Bowler; Kalia Cleridou; Hina Dadabhoy; Emma Davies; Ashlyn Firkins; Sian Granville; Elizabeth Harding; Alexandra Hopkins; Daniel Isaacs; Janchai King; Danae Kokorikou; Christina Maurice; Cleo McIntosh; Jessica Memarzia; Harriet Mills; Ciara O’Donnell; Sara Pantaleone; Jenny Scott; Pasco Fearon; John Suckling; Anne-Laura van Ha...; Rogier Kievit
• Keywords: Adult; Male; head movement; Adolescent; Allen Human Brain Atlas; Neurodevelopment; Head Movement; 610; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Connectome; Humans; neurodevelopment; connectome; Brain; Biological Sciences; Adolescent Development; Magnetic Resonance Imaging; 3. Good health; Head Movements; Female; Nerve Net; MRI

Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change connectivity (FC) of resting-state oscillations between pairs 330 cortical regions and 16 subcortical 298 healthy adolescents scanned 520 times. Participants were aged 14 26 y on 1 3 occasions at least 6 mo apart. We found 2 distinct modes age-related FC: “conservative” “disruptive.” Conservative development was characteristic primary cortex, which strongly connected became even more the period from y. Disruptive association cortex regions, where remodeled: connections that weak stronger during adolescence, strong weaker. These quantified using maturational index (MI), estimated as Spearman’s correlation edgewise baseline FC (at y, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>F</mml:mi> <mml:msub> <mml:mrow> <mml:mi>C</mml:mi> </mml:mrow> <mml:mn>14</mml:mn> </mml:msub> </mml:math> ) adolescent ( <mml:mi mathvariant="normal">Δ</mml:mi> <mml:mo>−</mml:mo> <mml:mn>26</mml:mn> ), each region. systems (with negative MI) activated by social cognition autobiographical memory tasks prior fMRI data significantly colocated with maps aerobic glycolysis (AG), AG-related gene expression, postnatal surface expansion, shrinkage thickness. The presence these robust numerous sensitivity analyses. conclude organization is disrupted adolescence remodeling areas.