Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment

• DOI: 10.1073/pnas.1914112117
• Publication Date: 2019-12-17T22:15:55Z
• Authors: Gal Manella; Rona Aviram; Nityanand Bolshette; Sapir Muvkadi; Marina Golik; David F. Smith; Gad Asher
• Keywords: Hypoxia; Intermittent hypoxia; Chronobiology; Free-running sleep

Significance Circadian clocks are present in most cells of the body and act concert to coordinate our daily physiology behavior with environment. misalignment between environment has been implicated various pathologies. Here, we show that circadian can also occur different peripheral tissues following exposure hypoxia it stems from differential response core clock components hypoxia. Intertissue occurs upon intermittent hypoxia, a model for obstructive sleep apnea (OSA). Our findings highlight potential role internal pathophysiology OSA potentially other hypoxia-related diseases.