COST1 regulates autophagy to control plant drought tolerance

• DOI: 10.1073/pnas.1918539117
• Publication Date: 2020-03-14T00:04:44Z
• Authors: Yan Bao; Wei-Meng Song; Peipei Wang; Xiang Yu; Bei Li; Chunmei Jiang; Shin-Han Shiu; Hongxia Zhang; Diane C. Bassham
• Keywords: Drought Tolerance; Autophagosome

Plants balance their competing requirements for growth and stress tolerance via a sophisticated regulatory circuitry that controls responses to the external environments. We have identified plant-specific gene, COST1 ( constitutively stressed 1 ), is required normal plant but negatively regulates drought resistance by influencing autophagy pathway. An Arabidopsis thaliana cost1 mutant has decreased increased tolerance, together with constitutive expression of drought-response genes, while overexpression confers hypersensitivity reduced autophagy. The protein degraded upon dehydration, this degradation treatment inhibitors 26S proteasome or pathways. dependent on an active pathway, independent other known signaling pathways, indicating acts through regulation In addition, colocalizes autophagosomes autophagosome marker ATG8e adaptor NBR1, affects level physical interaction ATG8e, pivotal role in direct propose model which represses under optimal conditions, thus allowing growth. Under drought, degraded, enabling activation suppression enhance tolerance. Our research places as important regulator controlling between