Febrile temperature change modulates CD4 T cell differentiation via a TRPV channel-regulated Notch-dependent pathway

• DOI: 10.1073/pnas.1922683117
• Publication Date: 2020-08-25T00:31:34Z
• Authors: Danish Umar; Arundhoti Das; Suman Gupta; Somdeb Chattopadhyay; Debayan Sarkar; Gauri Mirji; Jeet Kalia; Gopalakrishnan An...; Jeannine Marie Du...; Satyajit Rath; Anna George; Vineeta Bal
• Keywords: TRPV

Significance Since fever is frequently a response to infection, immune responses likely occur commonly at temperatures. Are temperatures detected by cells, what molecular pathways are involved in this sensing, and the functional consequences? Our data show that CD4 T lymphocytes detect moderate temperature. A TRPV channel-mediated pathway involving Notch activation leads Th2 skewing of effector cell response. However, antigen presenting dendritic cells stimulate turn, temperature overproduce interleukin-12 counter skewing. The evolutionary genesis these consequences complex regulatory loop specific infectious circumstances are, thus, be great interest.