The AMPK-PP2A axis in insect fat body is activated by 20-hydroxyecdysone to antagonize insulin/IGF signaling and restrict growth rate
0301 basic medicine
Insecta
Fat Body
Gene Expression Regulation, Developmental
AMP-Activated Protein Kinases
Bombyx
Receptor, Insulin
03 medical and health sciences
Ecdysterone
Somatomedins
Larva
Animals
Body Size
Insect Proteins
Insulin
Drosophila
Protein Phosphatase 2
Signal Transduction
DOI:
10.1073/pnas.2000963117
Publication Date:
2020-04-11T00:15:50Z
AUTHORS (11)
ABSTRACT
Significance
Final body size determination in animals remains a long-standing puzzle in the field of developmental biology. In insects, insulin/insulin-like growth factor signaling (IIS) and the steroid hormone 20-hydroxyecdysone (20E) are mainly responsible for the growth rate and growth period, respectively, and consequently the final body size. Here, we report that 20E activates AMPK by up-regulating its gene expression and inducing sugar starvation. In turn, AMPK activates protein phosphatase 2A, which further dephosphorylates and inactivates key components in IIS in the fat body, and eventually suppresses the larval growth rate. These data answer the question of how 20E antagonizes IIS and modulates growth rate.
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