A mouse tissue atlas of small noncoding RNA

• DOI: 10.1073/pnas.2002277117
• Publication Date: 2020-09-25T23:30:28Z
• Authors: Alina Isakova; Tobias Fehlmann; Andreas Keller; Stephen R. Quake
• Keywords: Male; 0301 basic medicine; ddc:610; Sex Characteristics; 0303 health sciences; Brain; 610; Biological Sciences; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Organ Specificity; Animals; RNA, Small Untranslated; Female; Single-Cell Analysis; Transcriptome

Significance We report a systematic unbiased analysis of small RNA molecule expression in 11 different tissues of the model organism mouse. We discovered uncharacterized noncoding RNA molecules and identified that ∼30% of total noncoding small RNA transcriptome are distributed across the body in a tissue-specific manner with some also being sexually dimorphic. Distinct distribution patterns of small RNA across the body suggest the existence of tissue-specific mechanisms involved in noncoding RNA processing.