Immunity to commensal skin fungi promotes psoriasiform skin inflammation

• DOI: 10.1073/pnas.2003022117
• Publication Date: 2020-06-30T00:40:19Z
• Authors: Charlotte Hurabielle; Verena M. Link; Nicolas Bouladoux; Seong-Ji Han; Eric Dean Merrill; Yaima L. Lightfoot; Nickie Seto; Christopher K. E....; Margery Smelkinson; Oliver J. Harrison; Jonathan L. Linehan; Samira Tamoutounour; Michail S. Lionakis; Mariana J. Kaplan; Saeko Nakajima; Yasmine Belkaid
• Keywords: Human skin; Proinflammatory cytokine; Commensalism

Significance Tissues exposed to the environment are sites of exposure symbiotic microbes including fungi that continuously sensed by immune system. Here, we show immunity commensal skin can significantly aggravate tissue inflammation. Enhanced pathology caused preexposure depends on lymphocytes able produce cytokine IL-17 and formation extracellular traps neutrophils. We also found fungal prior experimental modeling psoriasis recapitulates features transcriptional landscape human lesional psoriatic skin. Together, our results propose recall responses directed directly promote inflammation exploration should be assessed in context microbiota.