CD8 T cells drive anorexia, dysbiosis, and blooms of a commensal with immunosuppressive potential after viral infection

• DOI: 10.1073/pnas.2003656117
• Publication Date: 2020-09-22T00:41:18Z
• Authors: Lara Labarta-Bajo; Anna Gramalla-Sch...; Romana R. Gerner; Katelynn R. Kazane; Gregory Humphrey; Tara Schwartz; Karenina Sanders; Austin Swafford; Rob Knight; Manuela Raffatellu; Elina I. Zúñiga
• Keywords: Anorexia; Dysbiosis; Viral infection

Infections elicit immune adaptations to enable pathogen resistance and/or tolerance and are associated with compositional shifts of the intestinal microbiome. However, a comprehensive understanding how infections pathogens that exhibit distinct capability spread persist differentially change microbiome, underlying mechanisms, relative contribution individual commensal species cell is still lacking. Here, we discovered mouse infection fast-spreading persistent (but not slow-spreading acute) isolate lymphocytic choriomeningitis virus induced large-scale microbiome characterized by increased Verrucomicrobia reduced Firmicute/Bacteroidetes ratio. Remarkably, most profound changes occurred transiently after isolate, were uncoupled from sustained viral loads, instead largely caused CD8 T responses cell-induced anorexia. Among taxa enriched virus,