Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy

Male Mice, Knockout 0303 health sciences Serine Endopeptidases Uterus Arteries Hypertension, Pregnancy-Induced Vascular Remodeling Mice Proteinuria 03 medical and health sciences Fertility Gene Expression Regulation Pregnancy Animals Humans Female Promoter Regions, Genetic Cells, Cultured Transcription Factors
DOI: 10.1073/pnas.2003913117 Publication Date: 2020-07-28T00:25:33Z
ABSTRACT
Significance In pregnancy, blood vessels in the uterus increase in size, providing more blood supply and nutrients to the growing fetus. Corin is an enzyme that boosts this process. In this study, we sought to understand how uterine corin production is controlled. In experiments with human uterine cells and pregnant mice, we identified a protein, called Krüppel-like factor 17 (KLF17), which turns on the corin gene in the pregnant uterus. In genetically modified mice, Klf17 deficiency prevents uterine corin production, decreases uterine vessel size, and causes high blood pressure in pregnancy. These results show that KLF17 is a gene-controlling protein important for uterus function in pregnancy.
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