Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy

• DOI: 10.1073/pnas.2003913117
• Publication Date: 2020-07-28T00:25:33Z
• Authors: Can Wang; Zhiting Wang; Meiling He; Tiantian Zhou; Yayan Niu; Shengxuan Sun; Hui Li; Ce Zhang; Shengnan Zhang; Meng Liu; Ying Xu; Ningzheng Dong; Qingyu Wu
• Keywords: Spiral artery

Spiral artery remodeling is an important physiological process in the pregnant uterus which increases blood flow to fetus. Impaired spiral contributes preeclampsia, a major disease pregnancy. Corin, transmembrane serine protease, up-regulated promote remodeling. To date, mechanism underlying uterine corin up-regulation remains unknown. Here we show that Krüppel-like factor (KLF) 17 key transcription for expression In cultured human endometrial cells, KLF17 binds CORIN promoter and enhances activity. Disruption of gene cells abolishes expression. mice, Klf17 uterus. deficiency prevents Corin Moreover, Klf17-deficient mice have poorly remodeled arteries develop gestational hypertension proteinuria. Together, our results reveal function regulating physiology