Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy
Male
Mice, Knockout
0303 health sciences
Serine Endopeptidases
Uterus
Arteries
Hypertension, Pregnancy-Induced
Vascular Remodeling
Mice
Proteinuria
03 medical and health sciences
Fertility
Gene Expression Regulation
Pregnancy
Animals
Humans
Female
Promoter Regions, Genetic
Cells, Cultured
Transcription Factors
DOI:
10.1073/pnas.2003913117
Publication Date:
2020-07-28T00:25:33Z
AUTHORS (13)
ABSTRACT
Significance
In pregnancy, blood vessels in the uterus increase in size, providing more blood supply and nutrients to the growing fetus. Corin is an enzyme that boosts this process. In this study, we sought to understand how uterine corin production is controlled. In experiments with human uterine cells and pregnant mice, we identified a protein, called Krüppel-like factor 17 (KLF17), which turns on the corin gene in the pregnant uterus. In genetically modified mice, Klf17 deficiency prevents uterine corin production, decreases uterine vessel size, and causes high blood pressure in pregnancy. These results show that KLF17 is a gene-controlling protein important for uterus function in pregnancy.
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