Hormone seasonality in medical records suggests circannual endocrine circuits

• DOI: 10.1073/pnas.2003926118
• Publication Date: 2021-02-02T17:49:41Z
• Authors: Avichai Tendler; Alon Bar; Netta Mendelsohn-...; Omer Karin; Yael Korem Kohanim; Lior Maimon; Tomer Milo; Moriya Raz; Avi Mayo; Amos Tanay; Uri Alon
• Keywords: Seasonality; Circannual rhythm

Significance We provide a dataset of millions hormone tests from medical records that shows seasonality with winter−spring peak in hormones for reproduction, growth, metabolism, and stress adaptation. Together long history studies on human function the indicates that, like other animals, humans may have physiological season basic biological functions. further use specific seasonal phases to suggest model circannual clock animals can keep track seasons, similar spirit circadian keeps time day.