TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease

• DOI: 10.1073/pnas.2009334117
• Publication Date: 2020-10-30T00:20:24Z
• Authors: Eun Ji Lee; Eunjeong Seo; Jin Won Kim; Sun Ah Nam; Jong Young Lee; Jaehee Jun; Sumin Oh; Minah Park; Eek-hoon Jho; Kyung Hyun Yoo; Jong Hoon Park; Yong Kyun Kim
• Keywords: PKD1; Hippo signaling pathway; Beta-catenin

Significance Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic renal disease, primarily caused by germline mutation of PKD1 or PKD2 , leading to end-stage disease. There are few cures for ADPKD, although many researchers trying find a cure. The Hippo signaling pathway regulates organ growth and cell proliferation. Transcriptional coactivator with PDZ-binding motif (TAZ) effector. In this study, we demonstrated that PKD1–TAZ–Wnt–β-catenin–c-MYC axis plays critical role in cystogenesis. Endo IWR1 treatment, which inhibited β-catenin activity via AXIN stabilization, reduced cyst an ADPKD model. Our findings provide potential therapeutic target against would be important clinical translation.