Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

• DOI: 10.1073/pnas.2010540117
• Publication Date: 2020-09-18T00:50:11Z
• Authors: Jan C. Holter; Soeren E. Pischke; Eline de Boer; Andreas Lind; Synne Jenum; Aleksander R. Holten; Kristian Tonby; Andreas Barratt-Due; Marina Sokolova; Camilla Schjalm; Viktoriia Chaban; Anette Kolderup; Trung Tran; Torleif Tollefsru...; Linda G. Skeie; Liv Hesstvedt; Vidar Ormåsen; Børre Fevang; Cathrine Austad; Karl Erik Müller; Cathrine Fladeby; Mona Holberg-Pete...; Bente Halvorsen; Fredrik Müller; Pål Aukrust; Susanne Dudman; Thor Ueland; Jan Terje Andersen; Fridtjof Lund-Joh...; Lars Heggelund; Anne M. Dyrhol-Riise; Tom E. Mollnes
• Keywords: Complement

Significance The new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated trigger this detrimental process. complement system a key player in immunity. Despite few reports local activation, there lack evidence that degree systemic activation occurs early patients, whether associated failure. This study shows number products are systemically, consistently, long-lastingly increased from admission during hospital stay. Notably, terminal sC5b-9 complex was Thus, inhibition an attractive therapeutic approach for treatment COVD-19.