Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot

• DOI: 10.1073/pnas.2011297117
• Publication Date: 2020-12-16T23:41:48Z
• Authors: Zhaoting Li; Lianghan Zhu; Honghao Sun; Yuexin Shen; Dandan Hu; Wenhao Wu; Yixin Wang; Chenggen Qian; Minjie Sun
• Keywords: 0301 basic medicine; Dendrimers; Mice, Inbred BALB C; Myeloid-Derived Suppressor Cells; Antineoplastic Agents; Dendritic Cells; Fluorine; Nanoconjugates; T-Lymphocytes, Regulatory; 3. Good health; Mice; 03 medical and health sciences; Cell Line, Tumor; Tumor Microenvironment; Animals; Immunologic Factors; Female; Reactive Oxygen Species; Platinum

Significance “Cold” tumors are good at camouflaging themselves, thus making it difficult for the immune system to recognize and to construct a great barrier for cancer immunotherapies. New methods that could awaken the immune system, enhance T cells and antigen-presenting cells (APCs) trafficking, and relieve immunosuppression to treat cold tumors are urgently in need. Here, we first report a chemically ingenious nanocluster FS@PMPt assembly by fluorine–fluorine interaction to regulate the immune process. The nanocluster not only increased the infiltration of immunopositive cells from the outside but also decreased the immunosuppressive cells from the inside to break the shackles of immunosuppression, which provides a promising paradigm for improving the anti–cold tumor immunotherapy.