The V2 loop of HIV gp120 delivers costimulatory signals to CD4+T cells through Integrin α4β7and promotes cellular activation and infection

• DOI: 10.1073/pnas.2011501117
• Publication Date: 2020-12-07T22:15:28Z
• Authors: Livia R. Goes; Alia Sajani; Aida Sivro; Ronke Olowojesiku; Jocelyn C. Ray; Ian Perrone; Jason Yolitz; Alexandre Girard; Louise Leyre; Constantinos Kurt...; Lynn Morris; Giacomo Gorini; Genoveffa Franchini; Rosemarie D. Mason; Mario Roederer; Saurabh Mehandru; Marcelo A. Soares; Claudia Cicala; Anthony S. Fauci; James Arthos
• Keywords: V3 loop

Significance Understanding the early events in HIV transmission will aid development of an efficacious vaccine. Productive infection requires that virions access metabolically activated CD4 + T cells. These cells are, general, limited number, which contributes to inefficient viral transmission. This report describes a mechanism whereby gp120 envelope protein can deliver activating signals activity may increase both productive mucosal tissues around time and formation reservoirs. mediates by binding integrin α 4 β 7 . Antibodies specific V2 domain block this interaction contribute efficacy