Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties
Pore Forming Cytotoxic Proteins
0301 basic medicine
Mice
03 medical and health sciences
HEK293 Cells
Drug Design
Drug Evaluation, Preclinical
Animals
Humans
Bacteremia
Wasp Venoms
Microbial Sensitivity Tests
DOI:
10.1073/pnas.2012379117
Publication Date:
2020-10-13T00:30:35Z
AUTHORS (12)
ABSTRACT
Significance
Novel antibiotics are urgently needed to treat the ever-increasing number of drug-resistant infections. Venoms constitute a treasure trove of novel potential medicines. Here, we converted a peptide derived from venom into potent antimicrobials capable of resolving otherwise lethal infections in mice. We demonstrate that the peptide acts directly on bacteria by targeting their membrane, while also modulating the host immune response and dampening unwanted inflammation. Venom-derived molecules such as the ones described here represent an exciting new source of antibiotics.
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CITATIONS (73)
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