Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4

• DOI: 10.1073/pnas.2013877117
• Publication Date: 2020-11-20T02:02:51Z
• Authors: Pedro M. Moraes-V...; Mark M. Yore; Alexandra Sonthei...; Angela Castoldi; Julie Norseen; Pratik Aryal; Kotryna Simonyté ...; Barbara B. Kahn
• Keywords: Proinflammatory cytokine

Significance There is a growing need for insulin-sensitizing therapies to treat type 2 diabetes (T2D). In obese T2D humans, NLRP3 inflammasome activation contributes insulin resistance. Serum levels of retinol binding protein 4 (RBP4) are elevated in obese, insulin-resistant humans and RBP4 SNPs that increase adipose expression confer greater risk. correlate with many metabolic syndrome-related components, including cardiovascular disease. elevation induces resistance mice by increasing proinflammatory cytokine secretion from macrophages. Reducing dietary obesity decreases inflammation improves sensitivity. Here we show primes the which plays critical role RBP4-induced Thus, NLRP3-RBP4 axis may provide therapeutic strategies its comorbidities.