Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C

• DOI: 10.1073/pnas.2014940117
• Publication Date: 2020-10-15T23:20:49Z
• Authors: Kevin L. McKnight; Karen V. Swanson; Kathryn Austgen; Cindy Richards; Jonathan K. Mitchell; David R. McGivern; Ethan Fritch; John Johnson; Katja Remlinger; Michal Magid-Slav; Maryna Kapustina; Shihyun You; Stanley M. Lemon
• Keywords: Sting; Rhinovirus; Host factors; Host factors

Significance We show here that efficient replication of RV-A and RV-C viruses, common respiratory pathogens with positive-strand RNA genomes, requires STING, a host protein canonical function in innate immune responses to DNA viruses. STING is enriched PI4P-containing membranes organelles essential for step the viral genome. Its factor activity highly species-specific, adaptation RV-16 virus murine promotes cells origin. These findings add substantially current understanding factors restrict species range RVs limit development small animal models.