ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP

• DOI: 10.1073/pnas.2022600118
• Publication Date: 2021-03-15T22:14:40Z
• Authors: Jinhua Han; Li Wan; Guixing Jiang; Liping Cao; Feiyu Xia; Tian Tian; Xiaomei Zhu; Mingjie Wu; Michael S. Y. Huen; Yi Wang; Ting Liu; Jun Huang
• Keywords: DNA-PKcs

Significance A timely and appropriate response to genotoxic stress is essential for maintaining genome stability preventing tumorigenesis. Here, we have established a previously unidentified role of the protein kinase ATM in controlling extent DNA end resection during homology-directed repair. Specifically, elicits sequential posttranslational modifications key factor CtIP thereby fine-tunes its activity at DSB sites. Our findings highlight multistep roles master orchestrating damage responses.