Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans

• DOI: 10.1073/pnas.2025000118
• Publication Date: 2021-09-14T16:47:20Z
• Authors: Vinzenz Fleischer; Gabriel Gonzalez-...; Dumitru Ciolac; Philipp Albrecht; Patrick Küry; Joel Gruchot; Michael Dietrich; Christina Hecker; Thomas Müntefering; Stefanie Bock; Mohammadsaleh Osh...; Angela Radetz; Manuela Cerina; Julia Krämer; Lydia Wachsmuth; Cornelius Faber; Hans Lassmann; Tobias Ruck; Sven G. Meuth; Muthuraman Muthur...; Sergiu Groppa
• Keywords: ddc:004; Adult; Male; Proteomics; Encephalomyelitis, Autoimmune, Experimental; Multiple Sclerosis; Brain; Magnetic Resonance Imaging; Mice, Inbred C57BL; Disease Models, Animal; Mice; Blood-Brain Barrier; Choroid Plexus; Neuroinflammatory Diseases; Animals; Humans; Female

Significance Neuroinflammation is a hallmark of multiple sclerosis and is linked to neurodegeneration. This study provides pathophysiological insights into the cross-dependency between neuroinflammation and choroid plexus characteristics in both mice and humans. Our work relates an enlargement of choroid plexus volume to ongoing neuroinflammation and emerging clinical disability in two large cohorts of multiple sclerosis patients as well as in two mouse models, the cuprizone diet-related demyelination and the experimental autoimmune encephalomyelitis. Choroid plexus characterization as measured by high-resolution MRI thus represents a reliable and translatable interspecies marker for the quantification of neuroinflammation and disease trajectories that is strongly associated with functional outcomes.