Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo
Male
0301 basic medicine
0303 health sciences
Molecular Motor Proteins
Movement
Models, Biological
Vibration
Mice, Mutant Strains
Cochlea
Electrophysiology
Hair Cells, Auditory, Outer
Mice
03 medical and health sciences
Sound
Acoustic Stimulation
Hearing
Nonlinear Dynamics
Mice, Inbred CBA
Animals
Female
Organ of Corti
Tomography, Optical Coherence
DOI:
10.1073/pnas.2025206118
Publication Date:
2021-10-22T20:36:30Z
AUTHORS (5)
ABSTRACT
Significance
The remarkable high-frequency sensitivity of mammalian hearing depends on the amplification of sound-evoked cochlear vibrations by outer hair cells. One way that outer hair cells are proposed to generate amplifying forces is through voltage-driven changes in cell length. However, it remains unclear whether this electromotility can work fast enough in vivo to provide amplification at the necessary frequencies. Here, we show that sound elicits motions within the living mouse cochlea that are fully consistent with electromotility. These motions are large relative to the motion of the underlying cochlear partition, including at high frequencies. The data therefore suggest that electromotility can indeed provide high-speed amplification in vivo.
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