Deep genetic affinity between coastal Pacific and Amazonian natives evidenced by Australasian ancestry

• DOI: 10.1073/pnas.2025739118
• Publication Date: 2021-03-29T20:26:48Z
• Authors: Marcos Araújo Cas...; Tiago Ferraz; Maria Cátira Bort...; David Comas; Tábita Hünemeier
• Keywords: 0301 basic medicine; Human Migration; Australasian; Biological Sciences; South America; 16. Peace & justice; Evolution, Molecular; 03 medical and health sciences; Settlement of South America; Native Americans; Genetics; Humans; Pacific coastal route; Indigenous Peoples; American Indian or Alaska Native

Different models have been proposed to elucidate the origins of the founding populations of America, along with the number of migratory waves and routes used by these first explorers. Settlements, both along the Pacific coast and on land, have been evidenced in genetic and archeological studies. However, the number of migratory waves and the origin of immigrants are still controversial topics. Here, we show the Australasian genetic signal is present in the Pacific coast region, indicating a more widespread signal distribution within South America and implicating an ancient contact between Pacific and Amazonian dwellers. We demonstrate that the Australasian population contribution was introduced in South America through the Pacific coastal route before the formation of the Amazonian branch, likely in the ancient coastal Pacific/Amazonian population. In addition, we detected a significant amount of interpopulation and intrapopulation variation in this genetic signal in South America. This study elucidates the genetic relationships of different ancestral components in the initial settlement of South America and proposes that the migratory route used by migrants who carried the Australasian ancestry led to the absence of this signal in the populations of Central and North America.