Dietary ω-3 polyunsaturated fatty acids are protective for myopia

• DOI: 10.1073/pnas.2104689118
• Publication Date: 2021-10-21T20:33:16Z
• Authors: Miaozhen Pan; Fei Zhao; Bintao Xie; Hao Wu; Sen Zhang; Cong Ye; Zhenqi Guan; Lin Kang; Yuqing Zhang; Xuan Zhou; Yi Lei; Qi Wang; Li Wang; Fan Yang; Chenchen Zhao; Jia Qu; Xiangtian Zhou
• Keywords: Docosahexaenoic Acids; Choroid; Guinea Pigs; Administration, Oral; 3. Good health; Disease Models, Animal; Mice; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Eicosapentaenoic Acid; Cell Transdifferentiation; Dietary Supplements; Fatty Acids, Omega-3; Disease Progression; Myopia; Animals; Humans; Hypoxia; Myofibroblasts; Cells, Cultured

Myopia is a leading cause of visual impairment and blindness worldwide. However, safe accessible approach for myopia control prevention currently unavailable. Here, we investigated the therapeutic effect dietary supplements omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on progression in animal models decreases choroidal blood perfusion (ChBP) caused by near work, risk factor young adults. We demonstrated that daily gavage ω-3 PUFAs (300 mg docosahexaenoic acid [DHA] plus 60 eicosapentaenoic [EPA]) significantly attenuated development form deprivation guinea pigs mice, as well lens-induced pigs. Peribulbar injections DHA also inhibited form-deprived The suppression was accompanied inhibition "ChBP reduction-scleral hypoxia cascade." Additionally, treatment with or EPA antagonized hypoxia-induced myofibroblast transdifferentiation cultured human scleral fibroblasts. In subjects, oral administration partially alleviated near-work-induced ChBP. Therefore, evidence from these studies suggests are potential readily available candidates control.