MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection

• DOI: 10.1073/pnas.2106083119
• Publication Date: 2022-04-21T18:19:30Z
• Authors: Erietta Stelekati; Zhangying Cai; Sasikanth Manne; Zeyu Chen; Jean-Christophe B...; Lance Alec Buchness; Xuebing Leng; Svetlana Ristin; Kito Nzingha; Viktoriya Ekshyyan; Christina Niavi; Mohamed S. Abdel-...; Mohammed-Alkhatim...; Sydney Drury; Chi Wai Lau; Zhen Gao; Yuguang Ban; Simon K. Zhou; K. Mark Ansel; Makoto Kurachi; Martha S. Jordan; Alejandro V. Vill...; Shin Foong Ngiow; E. John Wherry
• Keywords: Chronic infection

Significance CD8 T cell exhaustion is a key underlying factor limiting immunity in chronic infections and cancer. Persistent antigen exposure antagonizes formation of functional memory cells that provide long-term protection and, instead, drives the development exhausted (T EX ). Improving persistence function major goal for reinvigorating immune responses against tumors. Here, we identify miR-29a as molecule attenuates enhances . Enforced expression alters transcriptome, resulting robust changes molecular pathways governed by fundamental transcription factors epigenetic modulators. Thus, enforced responses, exhaustion, represents target improving outcome immunotherapy.