HIF-1–regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation

• DOI: 10.1073/pnas.2109144118
• Publication Date: 2021-10-27T20:05:28Z
• Authors: Xiaoxu Liu; Peiling Xie; Na Hao; Miao Zhang; Yang Liu; Peijun Liu; Gregg L. Semenza; Jianjun He; Huimin Zhang
• Keywords: Chromatin immunoprecipitation; Tumor progression

Significance Breast cancer stem cells (BCSCs) have the property of infinite self-renewal. When these divide, they give rise to one BCSC and transient amplifying cell that can rapidly proliferate but only for a limited number divisions. Only BCSCs secondary (recurrent and/or metastatic) tumors. It is believed breast recurrence due survival small BCSCs. Because represent very minority within primary tumor, their unique characteristics may not be detected by bulk tumor analyses. are often located regions intratumoral hypoxia, hypoxia-inducible factors activate transcription genes promote specification maintenance.