CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation

• DOI: 10.1073/pnas.2111804119
• Publication Date: 2022-03-30T18:44:27Z
• Authors: Daniel Hwang; Maryam S. Seyedsadr; Larissa Lumi Wata...; Alexandra Boehm; Ziver Sahin; Giacomo Casella; Soohwa Jang; Michael V. Gonzalez; James P. Garifallou; Hakon Hakonarson; Weifeng Zhang; Dan Xiao; Abdolmohamad Rostami; Guang-Xian Zhang; Bogoljub Ciric
• Keywords: Encephalomyelitis

Significance Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are diseases characterized by accumulation of myeloid cells in the central nervous system (CNS). Both harmful beneficial present EAE/MS, a goal MS therapy is to preferentially remove cells. The receptor for CSF-1 (CSF-1R) found on important their survival. CSF-1R can bind two ligands, IL-34, but it not known whether functions EAE/MS differ. We that blocking depleted only CNS suppressed EAE, whereas IL-34 had no effect. Thus, we propose could be MS.