Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance

• DOI: 10.1073/pnas.2112466118
• Publication Date: 2021-11-15T21:26:55Z
• Authors: Hélène Roumes; Charlotte Jollé; Jordy Blanc; Imad Benkhaled; Carolina Piletti ...; Philippe Massot; Gérard Raffard; Véronique Bouchaud; Marc Biran; Catherine Pythoud; Nicole Déglon; Eduardo R. Zimmer; Luc Pellerin; Anne-Karine Bouzi...
• Keywords: Barrel cortex; Premovement neuronal activity

Significance For decades, it was claimed that glucose the sole and sufficient energy substrate to sustain neuronal activity brain function. Our results challenge this view by demonstrating despite availability, lactate shuttling from astrocytes neurons via monocarboxylate transporters is necessary give rise blood oxygen level-dependent signal (used as a surrogate marker for activation) in rat cerebral cortex following whisker stimulation. Moreover, turned out be also essential sustaining behavioral performance associated with activation of barrel cortex. These findings call reappraisal neuroenergetics role determining