Exploiting breakdown in nonhost effector–target interactions to boost host disease resistance

• DOI: 10.1073/pnas.2114064119
• Publication Date: 2022-08-22T19:14:57Z
• Authors: Hazel McLellan; Sarah E. Harvey; Jens Steinbrenner; Miles R. Armstrong; Qin He; Rachel Clewes; Leighton Pritchard; Wei Wang; Shumei Wang; Thomas Nussbaumer; Bushra Dohai; Qingquan Luo; Priyanka Kumari; Hui Duan; Ana Roberts; Petra C. Boevink; Christina Neumann; Nicolas Champouret; Ingo Hein; Pascal Falter-Braun; Jim Beynon; Katherine Denby; Paul R. J. Birch
• Keywords: Phytophthora infestans; Oomycete

Plants are resistant to most microbial species due nonhost resistance (NHR), providing broad-spectrum and durable immunity. However, the molecular components contributing NHR poorly characterised. We address question of whether failure pathogen effectors manipulate plants plays a critical role in NHR. RxLR (Arg-any amino acid-Leu-Arg) from two oomycete pathogens,