Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction

• DOI: 10.1073/pnas.2115139119
• Publication Date: 2022-02-16T21:45:39Z
• Authors: Florian Reizine; Murielle Grégoire; Mathieu Lesouhaitier; Valentin Coirier; Juliette Gauthier; Céline Delaloy; Elise Dessauge; Florent Creusat; Fabrice Uhel; Arnaud Gacouin; Frédéric Dessauge; Cécile Le Naoures; Caroline Moreau; Claude Bendavid; Yoann Daniel; Kilian Petitjean; Valérie Bordeau; Claire Lamaison; Caroline Piau; Vincent Cattoir; Mikael Roussel; Bernard Fromenty; Christian Michelet; Yves Le Tulzo; Jaroslaw Zmijewski; Ronan Thibault; Michel Cogné; Karin Tarte; Jean-Marc Tadié
• Keywords: [SDV]Life Sciences [q-bio]; T-Lymphocytes; 610; Biological Availability; [SDV.CAN]Life Sciences [q-bio]/Cancer; Arginine; Lymphocyte Activation; T-Lymphocytes, Regulatory; sepsis; Mice; [SDV.CAN] Life Sciences [q-bio]/Cancer; Sepsis; 617; Immune Tolerance; Animals; Immunosuppression Therapy; Myeloid-Derived Suppressor Cells; T cell; Biological Sciences; Mitochondria; 3. Good health; mitochondria; [SDV] Life Sciences [q-bio]; Mice, Inbred C57BL; Disease Models, Animal; citrulline; Citrulline; Cytokines; Female

Significance Since sepsis induces a sustained immunosuppression responsible for secondary infections acquisition and late mortality, restoring immune function would result in a better outcome. Given the role of arginine deficiency in T cell dysfunction, the evaluation of restoring arginine availability in sepsis has to be explored. Using an animal model of sepsis, we demonstrated that increasing arginine availability enhanced mitochondrial T cell function and decreased sepsis-induced immunosuppression.