Intestinal commensal microbiota and cytokines regulate Fut2+Paneth cells for gut defense

• DOI: 10.1073/pnas.2115230119
• Publication Date: 2022-01-13T21:42:28Z
• Authors: Mariko Kamioka; Yoshiyuki Goto; Kiminori Nakamura; Yuki Yokoi; Rina Sugimoto; Shuya Ohira; Yosuke Kurashima; Shingo Umemoto; Shintaro Sato; Jun Kunisawa; Yu Takahashi; Steven E. Domino; Jean-Christophe R...; Susumu Nakae; Yoichiro Iwakura; Peter B. Ernst; Tokiyoshi Ayabe; Hiroshi Kiyono
• Keywords: Paneth cell

Paneth cells are intestinal epithelial that release antimicrobial peptides, such as α-defensin part of host defense. Together with mesenchymal cells, provide niche factors for stem cell homeostasis. Here, we report two subtypes murine differentiated by their production and utilization fucosyltransferase 2 (Fut2), which regulates α(1,2)fucosylation to create cohabitation niches commensal bacteria prevent invasion the intestine pathogenic bacteria. The majority Fut2- were localized in duodenum, whereas Fut2+ ileum. showed higher granularity structural complexity than did suggesting involved Signaling bacteria, together interleukin 22 (IL-22), induced development cells. IL-22 was found affect secretion system via modulation Fut2 expression, IL-17a increase tract. Thus, these cytokines regulate function gut