Human leukocytes selectively convert 4 S ,5 S -epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer

• DOI: 10.1073/pnas.2116559118
• Publication Date: 2021-12-15T21:55:47Z
• Authors: Ashley E. Shay; Robert Nshimiyimana; Bengt Samuelsson; Nicos A. Petasis; Jesper Z. Haeggström; Charles N. Serhan
• Keywords: 0301 basic medicine; 03 medical and health sciences; Granuloma; Macrophages; Fatty Acids, Unsaturated; Leukocytes; Humans; Cells, Cultured; 3. Good health

Significance The resolution of the acute inflammatory response is an active, highly organized process essential for tissue regeneration, wound healing, and return to homeostasis that involves specialized proresolving mediators (SPMs). elucidation play roles in these processes general interest since many widely occurring diseases display unresolved inflammation their pathobiology. Here, we document pivotal role 4 S ,5 -epoxy-resolvin as intermediate biosynthesis resolvin D3 D4 identified a unique cysteinyl-resolvin isomer biosynthesized cell type–specific manner. Results from cell- model organism–based systems each defined potent bioactivity isomer.