Adolescent development of multiscale structural wiring and functional interactions in the human connectome

• DOI: 10.1073/pnas.2116673119
• Publication Date: 2022-07-01T16:05:06Z
• Authors: Bo-yong Park; Casey Paquola; Richard A. I. Bet...; Oualid Benkarim; ; Bratislav Mišić; Jonathan Smallwood; Edward T. Bullmore; Boris C. Bernhardt; Edward Bullmore; Raymond Dolan; Ian Goodyer; Peter Fonagy; Peter Jones; Michael Moutoussis; Tobias Hauser; Sharon Neufeld; Rafael Romero-Garcia; Michelle St Clair; Petra Vértes; Kirstie Whitaker; Becky Inkster; Gita Prabhu; Cinly Ooi; Umar Toseeb; Barry Widmer; Junaid Bhatti; Laura Villis; Ayesha Alrumaithi; Sarah Birt; Aislinn Bowler; Kalia Cleridou; Hina Dadabhoy; Emma Davies; Ashlyn Firkins; Sian Granville; Elizabeth Harding; Alexandra Hopkins; Daniel Isaacs; Janchai King; Danae Kokorikou; Christina Maurice; Cleo McIntosh; Jessica Memarzia; Harriet Mills; Ciara O’Donnell; Sara Pantaleone; Jenny Scott; Beatrice Kiddle; Ela Polek; Pasco Fearon; John Suckling; Anne-Laura van Ha...; Rogier Kievit; Sam Chamberlain
• Keywords: Structural plasticity; Human Connectome Project; Human brain; Longitudinal Study

Adolescence is a time of profound changes in the physical wiring and function brain. Here, we analyzed structural functional brain network development an accelerated longitudinal cohort spanning 14 to 25 y ( n = 199). Core our work was advanced vivo model cortical incorporating MRI features corticocortical proximity, microstructural similarity, white matter tractography. Longitudinal analyses assessing age-related identified continued differentiation multiple networks youth. We then assessed structure–function coupling using resting-state measures same participants both via cross-sectional analysis at baseline by studying change between follow-up scans. At baseline, regions with more similar were likely be functionally coupled. Moreover, correlating connectivity reconfigurations, found that increased differentiation, particularly sensory/unimodal default mode networks, reflected reduced interactions. These findings provide insights into adolescent human structure function, illustrating how interacts maturation macroscale hierarchies.