Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels

• DOI: 10.1073/pnas.2117209119
• Publication Date: 2022-03-30T18:44:27Z
• Authors: Renfei Qi; Junping Cao; Yufang Sun; Yanping Li; Zitong Huang; Dongsheng Jiang; Xing-Hong Jiang; Terrance P. Snutch; Yuan Zhang; Jin Tao
• Keywords: 0301 basic medicine; Sensory Receptor Cells; Cav3.2 ; Microrna ; Neuropathic Pain ; T-type Ca2+ Channels ; Trigeminal Ganglion Neurons; Down-Regulation; Biological Sciences; Methylation; Rats; Histones; Rats, Sprague-Dawley; MicroRNAs; 03 medical and health sciences; Ganglia, Spinal; Animals; Neuralgia

Significance In this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to promoter region miR-32-5p gene and decreases expression miR-32-5p, turn promoting development pain through regulation Cav3.2 channels. miRNA-mediated has been proposed therapeutic approach Our findings replenishment strategy for treating chronic