Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks

• DOI: 10.1073/pnas.2120808119
• Publication Date: 2022-05-02T19:05:14Z
• Authors: Elie M. Adam; Emery N. Brown; Nancy Kopell; Michelle M. McCarthy
• Keywords: Subthalamic Nucleus; Brain stimulation

Significance Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is highly effective for treating motor symptoms of Parkinson’s disease (PD). However, neural mechanisms by which DBS acts are unknown. PD tied to altered rhythms basal ganglia (BG) and particularly striatum. We develop a biophysical model BG pathway show how beta oscillations can emerge throughout PD. then establish mechanism STN interrupt these abnormal restore brain’s capability produce regulate normal lost with dopamine depletion. Our research suggests leverage striatal gamma theta counter aberrant dynamics enhance therapeutic effects DBS.