Tagged actin mRNA dysregulation in IGF2BP1−/− mice

• DOI: 10.1073/pnas.2208465119
• Publication Date: 2022-09-06T17:57:56Z
• Authors: Leti Núñez; Adina R. Buxbaum; Zachary B. Katz; Melissa Lopez-Jones; Chiso Nwokafor; Kevin Czaplinski; Feng Pan; Jason Rosenberg; Hannah R. Monday; Robert H. Singer
• Keywords: 0301 basic medicine; 03 medical and health sciences

Gene expression is tightly regulated by RNA-binding proteins (RBPs) to facilitate cell survival, differentiation, and migration. Previous reports have shown the importance of Insulin-like Growth Factor II mRNA-Binding Protein (IGF2BP1/IMP1/ZBP1) in regulating RNA fate, including localization, transport, translation. Here, we generated characterized a knockout mouse study RBP regulation. We report that IGF2BP1 essential for proper brain development neonatal survival. Specifically, these mice display disorganization developing neocortex, further investigation revealed loss cortical marginal density at E17.5. also investigated migratory populations IGF2BP1[Formula: see text] mice, using BrdU labeling, detected fewer mitotically active cells plate. Since localization important cellular migration directionality, regulation