IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

• DOI: 10.1073/pnas.2221116120
• Publication Date: 2023-05-16T17:42:19Z
• Authors: Yang Pan; John W. Phillips; Beatrice D. Zhang; Miyako Noguchi; Eric Kutschera; Jami McLaughlin; Pavlo A. Nesterenko; Zhiyuan Mao; Nathanael J. Bang...; Robert Wang; Wendy Tran; Harry T. Yang; Yuanyuan Wang; Yang Xu; Matthew B. Obusan; Donghui Cheng; Alex H. Lee; Kathryn E. Kadash...; Ameya Champhekar; Cristina Puig-Saus; Antoni Ribas; Robert M. Prins; Christopher S. Seet; Gay M. Crooks; Owen N. Witte; Yi Xing
• Keywords: IRIS (biosensor); Cancer Immunotherapy; Precursor mRNA

Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe