Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice

• DOI: 10.1073/pnas.222371099
• Publication Date: 2002-10-29T17:24:11Z
• Authors: Richard Wing-Chue...; Mitsutoshi Setou; Junlin Teng; Yosuke Takei; Nobutaka Hirokawa
• Keywords: 0301 basic medicine; Mice, Inbred ICR; DNA, Complementary; Base Sequence; Behavior, Animal; Molecular Motor Proteins; Molecular Sequence Data; Gene Expression; Kinesins; Mice, Transgenic; Receptors, N-Methyl-D-Aspartate; Mice; 03 medical and health sciences; Prosencephalon; Memory; Task Performance and Analysis; Animals; Female; Cyclic AMP Response Element-Binding Protein; Maze Learning

The kinesin superfamily proteins (KIFs) play essential roles in receptor transportation along the microtubules. KIF17 transports N -methyl- d -aspartate NR2B subunit vitro , but its role vivo is unknown. To clarify this role, we generated transgenic mice overexpressing tagged with GFP. exhibited enhanced learning and memory a series of behavioral tasks, up-regulated expression potential involvement transcriptional factor, cAMP-dependent response element-binding protein, increased phosphorylation protein. Our results suggest that motor protein contributes to neuronal events required for by trafficking fundamental -aspartate-type glutamate receptors.