OCA-B/Pou2af1 is sufficient to promote CD4 + T cell memory and prospectively identifies memory precursors

• DOI: 10.1073/pnas.2309153121
• Publication Date: 2024-02-22T18:48:56Z
• Authors: Wenxiang Sun; Erik P. Hughes; Heejoo Kim; Jelena Perovanovic; Krystal R. Charley; Bryant Perkins; Junhong Du; Andrea Ibarra; Amber R. Syage; J. Scott Hale; Matthew A. Williams; Dean Tantin
• Keywords: Interleukin-7 receptor; Memory cell; Ectopic expression; Precursor cell

The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting development effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA-B expression is sufficient improve antiviral recall responses, while having minimal effects on primary effector responses. At peak viral response, short-lived T cell populations expanded but increased Gadd45b Socs2 expression, precursor cells Bcl2 , Il7r, Tcf7 a per-cell basis. Using an mCherry reporter mouse line, observe high in CD4 + central cells. We early infection, endogenously elevated prospectively identifies with survival capability potential. Cumulatively, results demonstrate both necessary promote vivo can be used identify