A journey to your self: The vague definition of immune self and its practical implications

• DOI: 10.1073/pnas.2309674121
• Publication Date: 2024-05-09T17:16:19Z
• Authors: Balázs Koncz; Gergő Mihály Balogh; Máté Manczinger
• Keywords: Vagueness; Self-similarity; Similarity (geometry); Identification

The identification of immunogenic peptides has become essential in an increasing number fields immunology, ranging from tumor immunotherapy to vaccine development. nature the adaptive immune response is shaped by similarity between foreign and self-protein sequences, a concept extensively applied numerous studies. Can we precisely define degree self? Furthermore, do accurately In current work, aim unravel conceptual mechanistic vagueness hindering assessment self-similarity. Accordingly, demonstrate remarkably low consistency among commonly employed measures highlight potential avenues for future research.