Distinct potassium channels on pain-sensing neurons

• DOI: 10.1073/pnas.231376298
• Publication Date: 2002-07-26T14:32:33Z
• Authors: Matthew N. Rasband; Eunice W. Park; Todd W. Vanderah; Josephine Lai; Frank Porreca; James S. Trimmer
• Keywords: Homomeric; Nociceptor; Dorsal root ganglion; Sensory neuron

Differential expression of ion channels contributes functional diversity to sensory neuron signaling. We find nerve injury induced by the Chung model neuropathic pain leads striking reductions in voltage-gated K + (Kv) channel subunit dorsal root ganglia (DRG) neurons, suggesting a potential molecular mechanism for hyperexcitability injured nerves. Moreover, specific classes DRG neurons express distinct Kv combinations. Importantly, Kv1.4 is sole Kv1 α expressed smaller diameter that homomeric predominate Aδ and C fibers arising from these cells. These are presumably nociceptors, because they also VR-1 capsaicin receptor, calcitonin gene-related peptide, and/or Na SNS/PN3/Nav1.8. In contrast, larger associated with mechanoreception proprioception high levels Kv1.1 Kv1.2 without or other subunits, heteromers subunits on large, myelinated afferent axons extend