Distinct potassium channels on pain-sensing neurons
Homomeric
Nociceptor
Dorsal root ganglion
Sensory neuron
DOI:
10.1073/pnas.231376298
Publication Date:
2002-07-26T14:32:33Z
AUTHORS (6)
ABSTRACT
Differential expression of ion channels contributes functional diversity to sensory neuron signaling. We find nerve injury induced by the Chung model neuropathic pain leads striking reductions in voltage-gated K + (Kv) channel subunit dorsal root ganglia (DRG) neurons, suggesting a potential molecular mechanism for hyperexcitability injured nerves. Moreover, specific classes DRG neurons express distinct Kv combinations. Importantly, Kv1.4 is sole Kv1 α expressed smaller diameter that homomeric predominate Aδ and C fibers arising from these cells. These are presumably nociceptors, because they also VR-1 capsaicin receptor, calcitonin gene-related peptide, and/or Na SNS/PN3/Nav1.8. In contrast, larger associated with mechanoreception proprioception high levels Kv1.1 Kv1.2 without or other subunits, heteromers subunits on large, myelinated afferent axons extend
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