Prebiotic access to enantioenriched amino acids via peptide-mediated transamination reactions

• DOI: 10.1073/pnas.2315447121
• Publication Date: 2024-02-05T20:09:16Z
• Authors: Jinhan Yu; Andrea Darú; Min Deng; Donna G. Blackmond
• Keywords: Transamination; Enantiopure drug; Kinetic resolution; Racemization; Homochirality

The kinetic resolution of racemic amino acids mediated by dipeptides and pyridoxal provides a prebiotically plausible route to enantioenriched proteinogenic acids. enzymatic transamination cycles that are key modern biochemical formation enantiopure may have evolved from this half the reversible reaction couple. Kinetic precursors emerges as general enantioenrichment under prebiotic conditions.