Stereotyped and specific gene expression programs in human innate immune responses to bacteria

• DOI: 10.1073/pnas.231625398
• Publication Date: 2002-07-26T14:36:44Z
• Authors: Jennifer C. Boldrick; Ash A. Alizadeh; Maximilian Diehn; Sandrine Dudoit; Chih Long Liu; Christopher E. Be...; David Botstein; Louis M. Staudt; Patrick O. Brown; David A. Relman
• Keywords: Pathogenic bacteria

The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found remarkably stereotyped induced by lipopolysaccharide diverse killed bacteria. An intricately choreographed devoted communication between was prominent feature response. Other features suggested commitment antigen-presenting antigens captured context infection. Despite striking similarities, there were qualitative quantitative differences responses different Modulation host-response virulence mechanisms an important source variation