Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity, and pigment transfer

• DOI: 10.1073/pnas.2321323121
• Publication Date: 2024-04-12T16:48:15Z
• Authors: Marie-Thérèse Pro...; Cécile Giordano; Mireia Gomez-Duro; Ilse Hurbain; Anne-Sophie Macé; Graça Raposo; Gisela D’Angelo
• Keywords: Melanosome; Melanocyte; Epidermis (zoology)

Extracellular vesicles (EVs) facilitate the transfer of proteins, lipids, and genetic material between cells are recognized as an additional mechanism for sustaining intercellular communication. In epidermis, communication melanocytes keratinocytes is tightly regulated to warrant skin pigmentation. Melanocytes synthesize melanin pigment in melanosomes that transported along dendrites prior keratinocytes. EVs secreted by modulate pigmentation [(A. Lo Cicero et al. , Nat. Commun. 6 7506 (2015)]. However, whether contribute processes essential melanocyte functions remains elusive. Here, we show keratinocyte enhance ability generate mature promote their efficient transfer. Further, carrying Rac1 induce important morphological changes, dendrite outgrowth, potentiate Hence, addition modulating pigmentation, exploit control plasticity capacity. These data demonstrate keratinocyte-derived EVs, regulating functions, major contributors cutaneous expand our understanding underlying via a paracrine EV-mediated