Conserved 5-methyluridine tRNA modification modulates ribosome translocation

• DOI: 10.1073/pnas.2401743121
• Publication Date: 2024-08-19T19:06:21Z
• Authors: Joshua D. Jones; Monika K. Franco; Rachel N. Giles; Daniel E. Eyler; Mehmet Tardu; Tyler J. Smith; Laura R. Snyder; Yury S. Polikanov; Robert T. Kennedy; Rachel O. Niederer; Kristin S. Koutmou
• Keywords: 0301 basic medicine; tRNA Methyltransferases; 03 medical and health sciences; Saccharomyces cerevisiae Proteins; RNA, Transfer; Protein Biosynthesis; Escherichia coli; Saccharomyces cerevisiae; RNA Processing, Post-Transcriptional; Ribosomes; Uridine

While the centrality of posttranscriptional modifications to RNA biology has long been acknowledged, function vast majority modified sites remains be discovered. Illustrative this, there is not yet a discrete biological role assigned for one most highly conserved modifications, 5-methyluridine at position 54 in tRNAs (m